Issue 46, 2011
From the journal:

Chemical Communications

Simultaneous immunoassay for the detection of two lung cancer markers using functionalized SERS nanoprobes†

Hyangah Chon,a   Sangyeop Lee,a   Soo-Young Yoon,b   Soo-Ik Chang,c   Dong Woo Lima  and  Jaebum Choo*a  

* Corresponding authors

a Department of Bionano Engineering, Hanyang University, Ansan 426-791, South Korea
E-mail: jbchoo@hanyang.ac.kr

b Department of Laboratory Medicine, Korea University College of Medicine, Ansan 425-707, South Korea

c Department of Biochemistry, Chungbuk National University, Cheongju 361-763, South Korea

Abstract

A quick and reproducible SERS-based immunoassay, using functionalized hollow gold nanospheres and magnetic beads, has been developed. Here, a simultaneous detection of dual cancer markers in blood serum has been achieved under a single excitation wavelength. The accuracy and sensitivity for clinical sera from five patients confirms their diagnostic feasibility.

Graphical abstract: Simultaneous immunoassay for the detection of two lung cancer markers using functionalized SERS nanoprobes

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Article information

DOI
https://doi.org/10.1039/C1CC15707H
Article type
Communication
Submitted
15 Sep 2011
Accepted
12 Oct 2011
First published
25 Oct 2011

Chem. Commun., 2011,47, 12515-12517

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Simultaneous immunoassay for the detection of two lung cancer markers using functionalized SERS nanoprobes

H. Chon, S. Lee, S. Yoon, S. Chang, D. W. Lim and J. Choo, Chem. Commun., 2011, 47, 12515 DOI: 10.1039/C1CC15707H

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