Issue 46, 2011

Histidinylated linear PEI: a new efficient non-toxic polymer for gene transfer

Abstract

A series of linear polyethylenimine (lPEI) substituted with histidine residue (His-lPEI) was synthesized using the Michael reaction in order to provide new highly efficient vectors for gene therapy applications (up to 95% of transfected cells) with remarkable low cytotoxicity compared to lPEI-based polyplexes.

Graphical abstract: Histidinylated linear PEI: a new efficient non-toxic polymer for gene transfer

Supplementary files

Article information

Article type
Communication
Submitted
15 Sep 2011
Accepted
12 Oct 2011
First published
24 Oct 2011

Chem. Commun., 2011,47, 12547-12549

Histidinylated linear PEI: a new efficient non-toxic polymer for gene transfer

E. Bertrand, C. Gonçalves, L. Billiet, J. P. Gomez, C. Pichon, H. Cheradame, P. Midoux and P. Guégan, Chem. Commun., 2011, 47, 12547 DOI: 10.1039/C1CC15716G

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