Issue 17, 2012
From the journal:

Chemical Communications

Highly enantioselective Mukaiyama aldol reaction in aqueous conditions using a chiral iron(ii) bipyridine catalyst†

Thierry Ollevier*a  and  Baptiste Plancqa  

* Corresponding authors

a Département de chimie, Université Laval, 1045 avenue de la Médecine, Québec (Québec), Canada
E-mail: thierry.ollevier@chm.ulaval.ca

Abstract

A highly enantioselective method for the catalytic Mukaiyama aldol reaction of silyl enol ethers with aldehydes in aqueous conditions was developed. The desired aldol products were obtained in excellent yields, diastereo- and enantioselectivities. Structural evidence of the pre-catalyst revealed an unprecedented heptadentate Fe(II) complex with the chiral bipyridine ligand.

Graphical abstract: Highly enantioselective Mukaiyama aldol reaction in aqueous conditions using a chiral iron(ii) bipyridine catalyst

  • This article is part of the themed collection: Chirality
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Article information

DOI
https://doi.org/10.1039/C1CC16409K
Article type
Communication
Submitted
14 Oct 2011
Accepted
26 Oct 2011
First published
27 Oct 2011

Chem. Commun., 2012,48, 2289-2291

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Highly enantioselective Mukaiyama aldol reaction in aqueous conditions using a chiral iron(II) bipyridine catalyst

T. Ollevier and B. Plancq, Chem. Commun., 2012, 48, 2289 DOI: 10.1039/C1CC16409K

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