Issue 6, 2012
From the journal:

Chemical Communications

Pt(iv) analogs of oxaliplatin that do not follow the expected correlation between electrochemical reduction potential and rate of reduction by ascorbate

Jenny Z. Zhang,†a   Ezequiel Wexselblatt,†b   Trevor W. Hambleya  and  Dan Gibson*b  

* Corresponding authors

a School of Chemistry, The University of Sydney, Australia

b Institute for Drug Research, School of Pharmacy, The Hebrew University, Jerusalem, Israel
E-mail: dang@ekmd.huji.ac.il

Abstract

In contrast to the Pt(IV) derivatives of cisplatin, Pt(IV) derivatives of oxaliplatin do not show the expected correlation between the electrochemical reduction potentials and rates of reduction by ascorbate. This is probably due to the lower ability of the amine and carboxylato ligands to form a bridge with the reducing agents to facilitate electron transfer.

Graphical abstract: Pt(iv) analogs of oxaliplatin that do not follow the expected correlation between electrochemical reduction potential and rate of reduction by ascorbate

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Article information

DOI
https://doi.org/10.1039/C1CC16647F
Article type
Communication
Submitted
26 Oct 2011
Accepted
17 Nov 2011
First published
29 Nov 2011

Chem. Commun., 2012,48, 847-849

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Pt(IV) analogs of oxaliplatin that do not follow the expected correlation between electrochemical reduction potential and rate of reduction by ascorbate

J. Z. Zhang, E. Wexselblatt, T. W. Hambley and D. Gibson, Chem. Commun., 2012, 48, 847 DOI: 10.1039/C1CC16647F

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