Issue 6, 2012

Low-loading asymmetric organocatalysis

Abstract

Asymmetric organocatalysis is now recognized as the third pillar of asymmetric synthesis. Recent years have witnessed increasing interest towards the use of highly active and stereoselective organocatalysts. This critical review documents the advances in the development of chiral organocatalysts which are systematically used in ≤3 mol% loading in all the sub-areas of the field, namely aminocatalysis, Brønsted acids and bases, Lewis acids and bases, hydrogen bond-mediated catalysis, phase transfer and N-heterocyclic carbene catalyses (194 references).

Graphical abstract: Low-loading asymmetric organocatalysis

Article information

Article type
Critical Review
Submitted
01 Aug 2011
First published
14 Dec 2011

Chem. Soc. Rev., 2012,41, 2406-2447

Low-loading asymmetric organocatalysis

F. Giacalone, M. Gruttadauria, P. Agrigento and R. Noto, Chem. Soc. Rev., 2012, 41, 2406 DOI: 10.1039/C1CS15206H

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