Issue 38, 2011
From the journal:

Dalton Transactions

Synthesis, structures and anti-malaria activity of some gold(i) phosphine complexes containing seleno- and thiosemicarbazonato ligands†

Anja Molter,a   Jörg Rust,b   Christian W. Lehmann,b   Ganesh Deepa,c   Peter Chiba*c  and  Fabian Mohr*a  

* Corresponding authors

a Fachbereich C - Anorganische Chemie, Bergische Universität Wuppertal, Wuppertal, Germany
E-mail: fmohr@uni-wuppertal.de

b Max-Planck-Institut für Kohlenforschung, Mülheim an der Ruhr, Germany (X-Ray crystallography)

c Institute of Medical Chemistry, Medical University of Vienna, Vienna, Austria
E-mail: peter.chiba@meduniwien.ac.at

Abstract

A series of both mono- and dinuclear gold(I) phosphine complexes containing monoanionic seleno- and thiosemicarbazones as ligands were prepared and fully characterized by spectroscopic methods and, in some cases, by single crystal X-ray diffraction. The in vitro anti-malaria activity of some of these compounds was investigated in chloroquine sensitive strains of Plasmodium falciparum. The IC50 results show that the sulfur containing compounds exhibit activity similar to that of chloroquine, whilst the selenium derivatives display only moderate anti-malaria activity.

Graphical abstract: Synthesis, structures and anti-malaria activity of some gold(i) phosphine complexes containing seleno- and thiosemicarbazonato ligands

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Article information

DOI
https://doi.org/10.1039/C1DT10885A
Article type
Paper
Submitted
10 May 2011
Accepted
15 Jul 2011
First published
30 Aug 2011

Dalton Trans., 2011,40, 9810-9820

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Synthesis, structures and anti-malaria activity of some gold(I) phosphine complexes containing seleno- and thiosemicarbazonato ligands

A. Molter, J. Rust, C. W. Lehmann, G. Deepa, P. Chiba and F. Mohr, Dalton Trans., 2011, 40, 9810 DOI: 10.1039/C1DT10885A

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