Issue 41, 2011

Targeted and multifunctional areneruthenium chemotherapeutics

Abstract

The introduction of multifunctionalities for tumour targeting is becoming a popular strategy toward the development of new therapeutic agents. In particular, the multifaceted potential of ruthenium(II)-arene complexes show great promise as chemotherapeutics. An ever-increasing number of papers dealing with the integration of ruthenium complexes with biologically active molecules to derive bioorganometallic molecules of chemotherapeutic significance have been published in recent years. This perspective review presents a short overview of multifunctional ruthenium-based drugs, especially those containing arene ruthenium complexes, with the emphasis on the combination of photosensitizers with ruthenium complexes for the preparation of novel multifunctional photodynamic therapy agents.

Graphical abstract: Targeted and multifunctional arene ruthenium chemotherapeutics

Article information

Article type
Perspective
Submitted
30 May 2011
Accepted
13 Jul 2011
First published
22 Aug 2011

Dalton Trans., 2011,40, 10793-10800

Targeted and multifunctional arene ruthenium chemotherapeutics

G. S. Smith and B. Therrien, Dalton Trans., 2011, 40, 10793 DOI: 10.1039/C1DT11007A

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