Cu2+-selective fluorescent chemosensor based on coumarin and its application in bioimaging

Liang Huang; Ju Cheng; Kefeng Xie; Pinxian Xi; Fengping Hou; Zhengpeng Li; Guoqiang Xie; Yanjun Shi; Hongyan Liu; Decheng Bai; Zhengzhi Zeng

doi:10.1039/C1DT11123J

Cu²⁺-selective fluorescent chemosensor based on coumarin and its application in bioimaging†

Liang Huang,^a Ju Cheng,^b Kefeng Xie,^c Pinxian Xi,^a Fengping Hou,^a Zhengpeng Li,^a Guoqiang Xie,^a Yanjun Shi,^a Hongyan Liu,^a Decheng Bai^b and Zhengzhi Zeng*^a

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^a Key Laboratory of Nonferrous Metals Chemistry and Resources Utilization of Gansu Province, State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, PR China
E-mail: zengzhzh@yahoo.com.cn
Fax: +86 931 8912582
Tel: +86 931 8610877

^b School of Basic Medical Sciences, Lanzhou University, Lanzhou, PR China

^c Lanzhou Petrochemical Research Center, Petrochemical Research Institute, PetroChina, Lanzhou, PR China

Abstract

A new fluorescent sensor L1 based on coumarin was synthesized. It shows high sensitivity and selectivity toward Cu²⁺ in aqueous solution. The complexation mode and corresponding quenching mechanism were elucidated by ESI-MS and DFT calculations. In addition, biological imaging studies have demonstrated that L1 can detect Cu²⁺ in living cells.

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Cu²⁺-selective fluorescent chemosensor based on coumarin and its application in bioimaging†

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Cu²⁺-selective fluorescent chemosensor based on coumarin and its application in bioimaging

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