Issue 44, 2011

Complexes in context: Attempting to control the cellular uptake and localisation of rheniumfac-tricarbonyl polypyridyl complexes

Abstract

Transition metal lumophores are now well established as agents for cell imaging, but we are still not able to predict generally and with confidence their cellular localisation, or, for that matter, their uptake efficiencies. While many such complexes have been shown to illuminate cells, genuine applications in biomedical research will only be developed when their uptake and localisation are better understood. This perspective is not a comprehensive review of luminescence, but is an overview of attempts to control uptake and localisation, focussing on a personal account of this group's development of imaging agents based on the Re(CO)3 bipyridine core, and our attempts to understand and control their cellular behaviour.

Graphical abstract: Complexes in context: Attempting to control the cellular uptake and localisation of rheniumfac-tricarbonyl polypyridyl complexes

Supplementary files

Article information

Article type
Perspective
Submitted
27 Jun 2011
Accepted
04 Aug 2011
First published
06 Sep 2011

Dalton Trans., 2011,40, 11663-11674

Complexes in context: Attempting to control the cellular uptake and localisation of rheniumfac-tricarbonyl polypyridyl complexes

R. G. Balasingham, M. P. Coogan and F. L. Thorp-Greenwood, Dalton Trans., 2011, 40, 11663 DOI: 10.1039/C1DT11219H

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