Issue 4, 2011
From the journal:

Green Chemistry

Efficient synthesis of 3,4-dihydropyrimidin-2-ones in low melting tartaric acid–urea mixtures†

Sangram Gore,ab   Sundarababu Baskaran*a  and  Burkhard Koenig*b  

* Corresponding authors

a Department of Chemistry, Indian Institute of Technology Madras, Chennai, India
E-mail: sbhaskar@iitm.ac.in
Fax: 0091-44-22570545
Tel: 0091-44-22574218

b Institut für Organische Chemie, Universität Regensburg, Regensburg, Germany
E-mail: burkhard.koenig@chemi.uniregensburg.de
Fax: +49 941 9431717
Tel: +49 941 9434576

Abstract

A general, efficient and green method for the synthesis of dihydropyrimidinones is described under mild conditions employing low melting mixtures of L-(+)-tartaric acid and urea derivatives as a novel reaction medium. The melt plays a triple role: as solvent, as catalyst and as reactant, furnishing highly functionalized dihydropyrimidinones in good to excellent yields.

Graphical abstract: Efficient synthesis of 3,4-dihydropyrimidin-2-ones in low melting tartaric acid–urea mixtures

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Article information

DOI
https://doi.org/10.1039/C1GC00009H
Article type
Paper
Submitted
03 Jan 2011
Accepted
07 Feb 2011
First published
04 Mar 2011

Green Chem., 2011,13, 1009-1013

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Efficient synthesis of 3,4-dihydropyrimidin-2-ones in low melting tartaric acid–urea mixtures

S. Gore, S. Baskaran and B. Koenig, Green Chem., 2011, 13, 1009 DOI: 10.1039/C1GC00009H

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