Issue 8, 2011
From the journal:

Green Chemistry

Replacing dichloroethane as a solvent for rhodium-catalysed intermolecular alkyne hydroacylation reactions: the utility of propylene carbonate†

Philip Lenden,a   Paul M. Ylioja,a   Carlos González-Rodríguez,a   David A. Entwistleb  and  Michael C. Willis*a  

* Corresponding authors

a Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, UK
E-mail: michael.willis@chem.ox.ac.uk
Fax: +44 1865 285002
Tel: +44 1865 285126

b Research API, Pfizer Global Research and Development, Sandwich, Kent, UK

Abstract

Propylene carbonate is an excellent solvent for rhodium-catalysed intermolecular alkyne hydroacylation reactions, allowing a variety of β-S-aldehydes and alkynes to be combined in high yields, to deliver enone products. The effective use of propylene carbonate removes the need to employ dichloroethane as solvent.

Graphical abstract: Replacing dichloroethane as a solvent for rhodium-catalysed intermolecular alkyne hydroacylation reactions: the utility of propylene carbonate

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Article information

DOI
https://doi.org/10.1039/C1GC15293A
Article type
Communication
Submitted
17 Mar 2011
Accepted
17 May 2011
First published
22 Jun 2011

Green Chem., 2011,13, 1980-1982

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Replacing dichloroethane as a solvent for rhodium-catalysed intermolecular alkyne hydroacylation reactions: the utility of propylene carbonate

P. Lenden, P. M. Ylioja, C. González-Rodríguez, D. A. Entwistle and M. C. Willis, Green Chem., 2011, 13, 1980 DOI: 10.1039/C1GC15293A

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