Enantioselective hydrogenation of α-ketoesters over alkaloid-modified platinum nanowires

Abstract

A green process for enantioselective hydrogenation of α-ketoesters over cinchona alkaloid-modified platinum (Pt) nanowires has been developed. Pt nanowires with a diameter of ∼1 nm were successfully synthesized, and used for the asymmetric hydrogenation of α-ketoesters in the presence of cinchona alkaloids under a low pressure at room temperature in water. Quantitative yields and excellent enantioselectivity of up to 78% were achieved. The catalyst along with the modifier was recycled multiple times without any significant loss in activity or selectivity. To our knowledge, such a catalyst system is unprecedented for asymmetric hydrogenation of α-ketoesters.