Issue 31, 2011
From the journal:

Journal of Materials Chemistry

Transformation of hydrophobic iron oxide nanoparticles to hydrophilic and biocompatible maghemite nanocrystals for use as highly efficient MRI contrast agent†

Yong Il Park,a   Yuanzhe Piao,*b   Nohyun Lee,a   Byeongjun Yoo,a   Byung Hyo Kim,a   Seung Hong Choic  and  Taeghwan Hyeon*a  

* Corresponding authors

a National Creative Research Initiative Center for Oxide Nanocrystalline Materials, World Class University (WCU) program of Chemical Convergence for Energy & Environment (C2E2), School of Chemical and Biological Engineering, Seoul National University, Seoul, Korea
E-mail: thyeon@snu.ac.kr
Fax: +82 2 886 8457
Tel: +82 2 880 7150

b Department of Nano Science and Technology, Graduate School of Convergence Science and Technology, Advanced Institutes of Convergence Technology, Seoul National University, Suwon, Korea
E-mail: parkat9@snu.ac.kr
Fax: +82 31 888 9148
Tel: +82 31 888 9141

c Diagnostic Radiology, Seoul National University Hospital and the Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul, Korea

Abstract

We report a transformation of hydrophobic iron oxide nanoparticles to hydrophilic and biocompatible maghemite nanocrystals by controlled thermal treatment followed by dextran coating. Sodium sulfate salt was used as matrix for preventing aggregation during the thermal treatment at high temperature. Through the thermal treatment and subsequent isolation process, highly crystalline bare maghemite nanocrystals with high magnetization were produced. Subsequent coating with dextran derivatives produced hydrophilic and biocompatible iron oxide nanocrystals. Among various kinds of dextran derivatives, polyanionic carboxymethyl dextran (CM-dextran) was most efficient for stabilizing the nanocrystals in aqueous media. CM-dextran coated nanocrystals exhibited high relaxivity originating from the high magnetization and assembled structure.

Graphical abstract: Transformation of hydrophobic iron oxide nanoparticles to hydrophilic and biocompatible maghemite nanocrystals for use as highly efficient MRI contrast agent

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Article information

DOI
https://doi.org/10.1039/C1JM10432B
Article type
Communication
Submitted
28 Jan 2011
Accepted
01 Mar 2011
First published
16 Mar 2011

J. Mater. Chem., 2011,21, 11472-11477

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Transformation of hydrophobic iron oxide nanoparticles to hydrophilic and biocompatible maghemite nanocrystals for use as highly efficient MRI contrast agent

Y. I. Park, Y. Piao, N. Lee, B. Yoo, B. H. Kim, S. H. Choi and T. Hyeon, J. Mater. Chem., 2011, 21, 11472 DOI: 10.1039/C1JM10432B

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