Issue 20, 2011

Apoferritin-camouflaged Pt nanoparticles: surface effects on cellular uptake and cytotoxicity

Abstract

Apoferritin-encapsulated Pt nanoparticles (AFt–Pt) were bio-mimetically prepared by an in situreduction method in the unique 8 nm spherical cage of apoferritin. The average size of AFt–Pt was 4.3 ± 0.9 nm. The spherical structure of apoferritin remained intact after loading Pt particles in its cavity. Apoferritin coating increased the amount of Pt internalized in HepG2 cells by about three times viareceptor-mediated endocytosis. AFt–Pt showed greatly improved biocompatibility compared with polyvinylpyrrolidone stabilized Pt nanoparticles (PVP–Pt). More than 80% of cells survived after treatment with 100 μM AFt–Pt for 48 h. By camouflaging the particles with a protein corona, apoferritin conferred a cell-recognizable identity to the particles, which strikingly ameliorated the bio-effects of the nanoparticles.

Graphical abstract: Apoferritin-camouflaged Pt nanoparticles: surface effects on cellular uptake and cytotoxicity

Article information

Article type
Paper
Submitted
08 Feb 2011
Accepted
15 Mar 2011
First published
07 Apr 2011

J. Mater. Chem., 2011,21, 7105-7110

Apoferritin-camouflaged Pt nanoparticles: surface effects on cellular uptake and cytotoxicity

X. Liu, W. Wei, C. Wang, H. Yue, D. Ma, C. Zhu, G. Ma and Y. Du, J. Mater. Chem., 2011, 21, 7105 DOI: 10.1039/C1JM10575B

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