Issue 42, 2011

Click-chemistry for nanoparticle-modification

Abstract

Both function and use of nanoparticles (NPs) to a great extent are dominated by interfacial energies, which in turn can be addressed by chemical modifications. This article focuses exclusively on the use of ‘click’-chemistry for NP-surface modification, also putting a major focus on the application of the resulting NPs in bio- and nanoscience. As ‘click’-chemistry is a universal method to link reaction partners in high efficiency, solvent insensitivity and at moderate reaction conditions, its use for engineering NP surfaces has become widespread. The basic approach of Cu(I)-catalyzed azide/alkyne-‘click’ (CuAAC) chemistry for NP-science is elucidated in this article, together with the applications of the resulting surface modified NPs in medicine, nanotechnology and bioassay-science.

Graphical abstract: Click-chemistry for nanoparticle-modification

Article information

Article type
Feature Article
Submitted
12 Apr 2011
Accepted
10 Jun 2011
First published
26 Jul 2011

J. Mater. Chem., 2011,21, 16717-16734

Click-chemistry for nanoparticle-modification

N. Li and W. H. Binder, J. Mater. Chem., 2011, 21, 16717 DOI: 10.1039/C1JM11558H

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