Issue 16, 2011

DNA tracking within a nanochannel: device fabrication and experiments

Abstract

Fabrication of nanochannels is drawing considerable interest due to its broad applications in nanobiotechnology (e.g. biomolecular sensing and single DNA manipulation). Nanochannels offer distinct advantages in allowing a slower translocation and multiple sensing spots along the channel, both of which improve the read-out resolution. However, implementing electrodes inside the nanochannel has rarely been demonstrated to our knowledge. The device described in this work is a Si–Glass anodically bonded Lab-on-a-Chip (LOC) device of a few millimetres in size capable of performing DNA manipulation. The LOC device structure is based on two mainstream microchannels interconnected by nanochannels. DNA, once trapped within the nanochannel, has been tracked throughout the length of the channel and the data have been recorded and analysed.

Graphical abstract: DNA tracking within a nanochannel: device fabrication and experiments

Article information

Article type
Paper
Submitted
27 Jan 2011
Accepted
02 Jun 2011
First published
06 Jul 2011

Lab Chip, 2011,11, 2711-2719

DNA tracking within a nanochannel: device fabrication and experiments

V. R. S. S. Mokkapati, V. Di Virgilio, C. Shen, J. Mollinger, J. Bastemeijer and A. Bossche, Lab Chip, 2011, 11, 2711 DOI: 10.1039/C1LC20075E

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