Issue 10, 2011

The biological occurrence and trafficking of cobalt

Abstract

Cobalt is an essential trace element in both prokaryotes and eukaryotes. Nevertheless, it occurs less frequently in metalloproteins than other transition metals. This low occurrence appears to be due to the metal's low abundance in nature as well as its competition with iron, whose biologically critical functions include respiration and photosynthesis. In this review, we discuss the biological role of cobalt, the major effects of cobalt on iron utilization, as well as several mechanisms that cells have developed to circumvent the toxicity of cobalt while still exploiting its chemistry.

Graphical abstract: The biological occurrence and trafficking of cobalt

Article information

Article type
Minireview
Submitted
26 May 2011
Accepted
19 Jul 2011
First published
01 Aug 2011

Metallomics, 2011,3, 963-970

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