Dendrimers as non-viral vectors for siRNA delivery

Abstract

There is a tremendous interest in moving siRNA therapeutics into a clinical setting for the treatment of various diseases. This in itself however depends largely on the availability of safe and efficient siRNA delivery systems. In this context, dendrimers have attracted considerable attention as siRNA vectors due to their well-defined structures and multivalent features. The present review offers a brief overview of the current status of dendrimers as siRNA delivery vectors, focusing on the different dendrimers investigated for their siRNA delivery ability and the related structural alterations employed to improve their safety and efficiency for this purpose.