Issue 10, 2011
From the journal:

Nanoscale

Controlled drug release characteristics and enhanced antibacterial effect of graphenenanosheets containing gentamicin sulfate†

Himanshu Pandey,‡*ab   Vyom Parashar,‡*b   Rashmi Parashar,c   Rajiv Prakash,d   Promod W. Ramtekea  and  Avinash C. Pandeyb  

* Corresponding authors

a Department of Pharmaceutical Science, Faculty of Health, Medical Sciences, Indigenous & Alternative Systems of Medicine, Sam Higginbottom Institute of Agriculture, Technology and Sciences, Allahabad, India
E-mail: himanshu.nac@gmail.com
Fax: +91 (532)2684394
Tel: +91 (532)2684147

b Nanotechnology Application Centre, Faculty of Science, University of Allahabad, Allahabad, India
E-mail: vyomparashar@gmail.com
Fax: +91 (532)2460675
Tel: +91 (532)2460675

c Department of Biochemistry, Faculty of Science, University of Allahabad, Allahabad, India

d School of Materials Science and Technology, Institute of Technology, Banaras Hindu University, Varanasi, India

Abstract

A novel methanol derived graphene (MDG) and gentamicin sulfate nanohybrid was prepared, and the loading and release behaviour of gentamicin on MDG is investigated. An efficient drug loading of 2.57 mg mg−1 was obtained at pH 7. By applying release kinetic models, the mechanism of release of the drug from the MDG matrix was found to be following the Korsmeyer–Peppas model. However, the diffusional release exponent (n) value lies below 0.5 demonstrating that the mechanism controlling the drug release is the Fickian diffusion.

Graphical abstract: Controlled drug release characteristics and enhanced antibacterial effect of graphene nanosheets containing gentamicin sulfate

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Article information

DOI
https://doi.org/10.1039/C1NR10661A
Article type
Communication
Submitted
22 Jun 2011
Accepted
15 Aug 2011
First published
12 Sep 2011

Nanoscale, 2011,3, 4104-4108

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Controlled drug release characteristics and enhanced antibacterial effect of graphene nanosheets containing gentamicin sulfate

H. Pandey, V. Parashar, R. Parashar, R. Prakash, P. W. Ramteke and A. C. Pandey, Nanoscale, 2011, 3, 4104 DOI: 10.1039/C1NR10661A

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