Issue 9, 2011
From the journal:

Organic & Biomolecular Chemistry

The importance of the N–H bond in Ru/TsDPEN complexes for asymmetric transfer hydrogenation of ketones and imines†

Rina Soni,a   Fung Kei Cheung,a   Guy C. Clarkson,a   Jose E. D. Martins,a   Mark A. Grahamb  and  Martin Wills*a  

* Corresponding authors

a Department of Chemistry, The University of Warwick, Coventry, UK
E-mail: m.wills@warwick.ac.uk
Fax: +44 24 7652 3260
Tel: +44 24 7652 4112

b Cancer & Infection Chemistry, AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire, UK

Abstract

Ru(II) complexes of TsDPEN containing two alkyl groups on the non-tosylated nitrogen atom are poor catalysts for asymmetric transfer hydrogenation of ketones and imines; this observation provides direct evidence for the importance of the N–H interaction in the transition state for ketone reduction.

Graphical abstract: The importance of the N–H bond in Ru/TsDPEN complexes for asymmetric transfer hydrogenation of ketones and imines

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Article information

DOI
https://doi.org/10.1039/C1OB05208J
Article type
Paper
Submitted
20 Nov 2011
Accepted
21 Feb 2011
First published
24 Feb 2011

Org. Biomol. Chem., 2011,9, 3290-3294

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The importance of the N–H bond in Ru/TsDPEN complexes for asymmetric transfer hydrogenation of ketones and imines

R. Soni, F. K. Cheung, G. C. Clarkson, J. E. D. Martins, M. A. Graham and M. Wills, Org. Biomol. Chem., 2011, 9, 3290 DOI: 10.1039/C1OB05208J

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