Issue 18, 2011

Efficient and simple zinc-mediated synthesis of 3-amidoindoles

Abstract

A general synthesis of 3-amidoindoles from easily available arylhydrazines and acylated propargylamines is described. In the presence of inexpensive Zn salts, alkyne amination and subsequent Fischer indole-cyclization took place in good yields with excellent regioselectivity providing an interesting scaffold for potentially bio-active compounds.

Graphical abstract: Efficient and simple zinc-mediated synthesis of 3-amidoindoles

Supplementary files

Article information

Article type
Paper
Submitted
12 Apr 2011
Accepted
20 Jun 2011
First published
01 Aug 2011

Org. Biomol. Chem., 2011,9, 6331-6334

Efficient and simple zinc-mediated synthesis of 3-amidoindoles

A. Pews-Davtyan and M. Beller, Org. Biomol. Chem., 2011, 9, 6331 DOI: 10.1039/C1OB05576C

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