Issue 19, 2011

Direct enantioselective access to 4-substituted tetrahydroquinolines by catalytic asymmetric transfer hydrogenation of quinolines

Abstract

A convenient protocol for the enantioselective synthesis of 4-substituted tetrahydroquinolines has been developed. Chiral BINOL phosphoric acids promote the reduction of a wide range of 4-substituted quinolines with Hantzsch esters with good to high levels of enantioselectivity.

Graphical abstract: Direct enantioselective access to 4-substituted tetrahydroquinolines by catalytic asymmetric transfer hydrogenation of quinolines

Supplementary files

Article information

Article type
Paper
Submitted
01 Jun 2011
Accepted
11 Jul 2011
First published
12 Aug 2011

Org. Biomol. Chem., 2011,9, 6844-6850

Direct enantioselective access to 4-substituted tetrahydroquinolines by catalytic asymmetric transfer hydrogenation of quinolines

M. Rueping, T. Theissmann, M. Stoeckel and A. P. Antonchick, Org. Biomol. Chem., 2011, 9, 6844 DOI: 10.1039/C1OB05870C

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