Issue 22, 2011

The challenge of the lantibiotics: synthetic approaches to thioether-bridged peptides

Abstract

The unique antibacterial properties and structural complexity of the lantibiotics has stimulated considerable interest in the development of methodology to synthesise these peptides. One of the most challenging issues has been the synthesis of polycyclic peptides with multiple thioether bridges between side-chains, which are a characteristic feature of the lantibiotics. In this perspective, the different approaches to this problem, including solution-phase synthesis, solid-phase synthesis, biomimetic approaches and biotransformation strategies, are reviewed, highlighting the advances resulting from each of these approaches.

Graphical abstract: The challenge of the lantibiotics: synthetic approaches to thioether-bridged peptides

Article information

Article type
Perspective
Submitted
11 Jun 2011
Accepted
04 Aug 2011
First published
29 Sep 2011

Org. Biomol. Chem., 2011,9, 7606-7628

The challenge of the lantibiotics: synthetic approaches to thioether-bridged peptides

A. B. Tabor, Org. Biomol. Chem., 2011, 9, 7606 DOI: 10.1039/C1OB05946G

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