Issue 20, 2011

Signaling of hypochlorous acid by selective deprotection of dithiolane

Abstract

The selective signaling of hypochlorous acid by dithiolane-protected pyrene-aldehyde was investigated. Dithiolane derivative of pyrene-aldehyde was efficiently deprotected by hypochlorous acid to its corresponding aldehyde, which resulted in a prominent UV-vis and turn-on type fluorescence signaling. The signaling was not affected by the presence of other common alkali, alkaline earth metal ions, and anions. Interference from Hg2+ ions could be successfully circumvented by using Chelex-100 resin. Dithiolane also provided selectivity toward hypochlorous acid over other commonly used oxidant of hydrogen peroxide.

Graphical abstract: Signaling of hypochlorous acid by selective deprotection of dithiolane

Supplementary files

Additions and corrections

Article information

Article type
Paper
Submitted
24 Jun 2011
Accepted
15 Jul 2011
First published
05 Aug 2011

Org. Biomol. Chem., 2011,9, 7011-7015

Signaling of hypochlorous acid by selective deprotection of dithiolane

J. Hwang, M. G. Choi, J. Bae and S. Chang, Org. Biomol. Chem., 2011, 9, 7011 DOI: 10.1039/C1OB06012K

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