Issue 4, 2012

Effect of carboxylic acid on micelles of a neutral amphiphilic dendro-calix[4]arene

Abstract

An amphiphilic calix[4]arene bearing branched 3,4,5-tris(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)benzamide groups at the upper rim was synthesized and could increase the solubility of naproxen and ibuprofen in water through hydrogen bonding and π–π stacking interactions. The interactions between amphiphilic calix[4]arene and carboxylic acids such as naproxen and ibuprofen could reverse the direction of the branched substituents and change the shape and size of calixarene micelles from solid to hollow or linear ones.

Graphical abstract: Effect of carboxylic acid on micelles of a neutral amphiphilic dendro-calix[4]arene

Supplementary files

Article information

Article type
Paper
Submitted
10 Aug 2011
Accepted
17 Oct 2011
First published
18 Oct 2011

Org. Biomol. Chem., 2012,10, 729-735

Effect of carboxylic acid on micelles of a neutral amphiphilic dendro-calix[4]arene

H. Huang, D. Li, W. Wang, Y. Chen, K. Khan, S. Song and Y. Zheng, Org. Biomol. Chem., 2012, 10, 729 DOI: 10.1039/C1OB06358H

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