Hydroxyapatite-supported Cu(I)-catalysed cyanation of styrenyl bromides with K4[Fe(CN)6]: an easy access to cinnamonitriles

Debasree Saha; Laksmikanta Adak; M. Mukherjee; Brindaban C. Ranu

doi:10.1039/C1OB06467C

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Hydroxyapatite-supported Cu(i)-catalysed cyanation of styrenyl bromides with K₄[Fe(CN)₆]: an easy access to cinnamonitriles†

Debasree Saha,^a Laksmikanta Adak,^a M. Mukherjee^b and Brindaban C. Ranu*^a

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* Corresponding authors

^a Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata, India
E-mail: ocbcr@iacs.res.in
Fax: +91 3324732805

^b Surface Physics Division, Saha Institute of nuclear Physics, Kolkata, India

Abstract

An efficient cyanation of styrenyl bromides by K₄[Fe(CN)₆] has been achieved under the catalysis of hydroxyapatite-supported copper(I) producing a variety of functionalized cinnamonitriles in high yields. The stereochemistry of the styrenyl double bond is preserved during the process providing the same stereoisomer of product.

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Article information

DOI: https://doi.org/10.1039/C1OB06467C
Article type: Paper
Submitted: 26 Aug 2011
Accepted: 20 Oct 2011
First published: 25 Oct 2011

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Org. Biomol. Chem., 2012,10, 952-957

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Hydroxyapatite-supported Cu(I)-catalysed cyanation of styrenyl bromides with K₄[Fe(CN)₆]: an easy access to cinnamonitriles

D. Saha, L. Adak, M. Mukherjee and B. C. Ranu, Org. Biomol. Chem., 2012, 10, 952 DOI: 10.1039/C1OB06467C

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Organic & Biomolecular Chemistry