Issue 2, 2012
From the journal:

Organic & Biomolecular Chemistry

Ruthenium-catalysed oxidative synthesis of heterocycles from alcohols†

Andrew J. A. Watson,*a   Aoife C. Maxwellb  and  Jonathan M. J. Williamsa  

* Corresponding authors

a Department of Chemistry, University of Bath, Claverton Down, Bath, UK
E-mail: ajaw20@bath.ac.uk

b GlaxoSmithKline Research and Development, Gunnels Wood Road, Stevenage, UK

Abstract

Ruthenium-catalysed hydrogen transfer has been successfully used for the conversion of alcohols into either 2,3-dihydroquinazolines or quinazolines. The choice of reaction conditions allows for the selective formation of either heterocycle and the methodology can also be applied to the sulfonamide analogue.

Graphical abstract: Ruthenium-catalysed oxidative synthesis of heterocycles from alcohols

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Article information

DOI
https://doi.org/10.1039/C1OB06516E
Article type
Communication
Submitted
03 Sep 2011
Accepted
26 Sep 2011
First published
26 Sep 2011

Org. Biomol. Chem., 2012,10, 240-243

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Ruthenium-catalysed oxidative synthesis of heterocycles from alcohols

A. J. A. Watson, A. C. Maxwell and J. M. J. Williams, Org. Biomol. Chem., 2012, 10, 240 DOI: 10.1039/C1OB06516E

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