Issue 1, 2012

Mono thiomalonates as thioester enolate equivalents—enantioselective 1,4-addition reactions to nitroolefins under mild conditions

Abstract

Mono thiomalonates (MTMs) are introduced as thioester enolate equivalents. Asymmetric organocatalyzed conjugate addition reactions to nitroolefins proceed under mild conditions to afford synthetically useful γ-nitrothioesters with excellent yields and enantioselectivities.

Graphical abstract: Mono thiomalonates as thioester enolate equivalents—enantioselective 1,4-addition reactions to nitroolefins under mild conditions

Supplementary files

Article information

Article type
Paper
Submitted
26 Sep 2011
Accepted
03 Oct 2011
First published
08 Nov 2011

Org. Biomol. Chem., 2012,10, 110-113

Mono thiomalonates as thioester enolate equivalents—enantioselective 1,4-addition reactions to nitroolefins under mild conditions

P. Clerici and H. Wennemers, Org. Biomol. Chem., 2012, 10, 110 DOI: 10.1039/C1OB06638B

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