Issue 5, 2011
From the journal:

RSC Advances

Flash synthesis of TAC-101 and its analogues from 1,3,5-tribromobenzene using integrated flow microreactor systems†

Aiichiro Nagaki,a   Keita Imai,a   Heejin Kima  and  Jun-ichi Yoshida*a  

* Corresponding authors

a Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, Japan
E-mail: yoshida@sbchem.kyoto-u.ac.jp
Fax: +81-75-383-2725
Tel: +81-75-383-2726

Abstract

Sequential introduction of three electrophiles into 1,3,5-tribromobenzene based on Br/Li exchange reaction was achieved using an integrated flow microreactor system consisting of six micromixers and six microtube reactors. This method enables flash synthesis of TAC-101 and its analogues within 13 s in good yields on a preparative scale.

Graphical abstract: Flash synthesis of TAC-101 and its analogues from 1,3,5-tribromobenzene using integrated flow microreactor systems

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C1RA00377A
Article type
Communication
Submitted
28 Jun 2011
Accepted
10 Aug 2011
First published
07 Sep 2011

RSC Adv., 2011,1, 758-760

Permissions

Request permissions

Flash synthesis of TAC-101 and its analogues from 1,3,5-tribromobenzene using integrated flow microreactor systems

A. Nagaki, K. Imai, H. Kim and J. Yoshida, RSC Adv., 2011, 1, 758 DOI: 10.1039/C1RA00377A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements