Issue 7, 2011

Regioselective formation of medium-ring heterocycles of biological relevance by intramolecular cyclization

Abstract

This brief account describes our progress on the regioselective synthesis of medium-sized heterocycles. Formation of the medium-ring (seven-, eight-, nine-membered) oxa-, aza-, thia, oxa-thia- and aza-thia-heterocycles has been achieved by the intramolecular metal-mediated cyclization (especially Pd-catalyzed), diene and enyne metathesis, thiol-mediated cyclization, iodocyclization and azide-alkyne cycloaddition.

Graphical abstract: Regioselective formation of medium-ring heterocycles of biological relevance by intramolecular cyclization

Article information

Article type
Review Article
Submitted
20 Jul 2011
Accepted
13 Aug 2011
First published
13 Oct 2011

RSC Adv., 2011,1, 1152-1170

Regioselective formation of medium-ring heterocycles of biological relevance by intramolecular cyclization

K. C. Majumdar, RSC Adv., 2011, 1, 1152 DOI: 10.1039/C1RA00494H

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