Issue 1, 2012

Lipid-coated nanoscale coordination polymers for targeted delivery of antifolates to cancer cells

Abstract

Nanoscale coordination polymers (NCPs) have been demonstrated as an interesting platform for drug delivery, as they possess many advantages over small-molecule chemotherapeutics such as high payloads, lower systemic toxicity, tunability, and enhanced tumor uptake. Existing formulations for the delivery of methotrexate (MTX), an antifolate cancer drug, have very low drug loadings. Herein, we report the incorporation of MTX as a building block in an NCP formulation with exceptionally high drug loadings (up to 79.1 wt%) and the selective delivery of the NCP to cancer cells. Encapsulation of the NCP in a functionalized lipid bilayer allows for targeted delivery and controlled release to cancer cells. A phosphor can be doped into the NCPs for monitoring particle uptake by optical imaging. The lipid-coated and anisamide-targeted NCPs have superior in vitro efficacy against acute lymphoblastic leukemia cells when compared to the free drug.

Graphical abstract: Lipid-coated nanoscale coordination polymers for targeted delivery of antifolates to cancer cells

Supplementary files

Article information

Article type
Edge Article
Submitted
22 Jul 2011
Accepted
28 Sep 2011
First published
20 Oct 2011

Chem. Sci., 2012,3, 198-204

Lipid-coated nanoscale coordination polymers for targeted delivery of antifolates to cancer cells

R. C. Huxford, K. E. deKrafft, W. S. Boyle, D. Liu and W. Lin, Chem. Sci., 2012, 3, 198 DOI: 10.1039/C1SC00499A

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