Issue 12, 2011

Enantioselective rhodium-catalyzed arylation of electron-deficient alkenylarenes

Abstract

β-Substituted alkenyl-para-nitroarenes, an unexplored substrate class for catalytic asymmetric addition reactions, undergo highly enantioselective rhodium-catalyzed arylations with arylboronic acids in the presence of a dibenzylamide-containing chiral diene ligand. One example of the asymmetric arylation of an alkenyl-p-cyano-m-(trifluoromethyl)benzene is also presented.

Graphical abstract: Enantioselective rhodium-catalyzed arylation of electron-deficient alkenylarenes

Supplementary files

Article information

Article type
Edge Article
Submitted
30 Jul 2011
Accepted
23 Aug 2011
First published
08 Sep 2011

Chem. Sci., 2011,2, 2326-2331

Enantioselective rhodium-catalyzed arylation of electron-deficient alkenylarenes

A. Saxena and H. W. Lam, Chem. Sci., 2011, 2, 2326 DOI: 10.1039/C1SC00521A

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