Issue 2, 2012
From the journal:

Chemical Science

Recent progress in enantioselective synthesis of C3-functionalized oxindoles: rare earth metals take action

Ke Shen,a   Xiaohua Liu,a   Lili Lina  and  Xiaoming Feng*a  

* Corresponding authors

a Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, P. R. China
E-mail: xmfeng@scu.edu.cn
Fax: + 86 28 85418249
Tel: + 86 28 85418249

Abstract

The enantioselective synthesis of 3-functionalized oxindole derivatives has experienced an explosive development. This minireview introduces the recent application of rare earth (RE) metal complex catalysts in the synthesis of targeted frameworks. The direct addition reactions of 3-substituted oxindoles or isatins are described, together with a discussion of the catalytic mechanism and related transformations to pharmaceuticals.

Graphical abstract: Recent progress in enantioselective synthesis of C3-functionalized oxindoles: rare earth metals take action

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Article information

DOI
https://doi.org/10.1039/C1SC00544H
Article type
Minireview
Submitted
09 Aug 2011
Accepted
12 Sep 2011
First published
22 Sep 2011

Chem. Sci., 2012,3, 327-334

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Recent progress in enantioselective synthesis of C3-functionalized oxindoles: rare earth metals take action

K. Shen, X. Liu, L. Lin and X. Feng, Chem. Sci., 2012, 3, 327 DOI: 10.1039/C1SC00544H

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