Issue 18, 2011

Block liposome and nanotube formation is a general phenomenon of two-component membranes containing multivalent lipids

Abstract

We report a study on the formation of block liposomes (BLs) and nanotubes from membranes comprising mixtures of membrane curvature-stabilizing multivalent cationic lipids MVL3(3+) and MVL5(5+) with neutral 1,2-dioleoyl-sn-glycero-3-phosphatidylcholine (DOPC). In conjunction with prior work on MVLBG2(16+), our experiments suggest that BL and nanotube formation is a general phenomenon in membranes containing multivalent lipids, thus enhancing the relevance of BLs for applications such as gene/drug storage and delivery or templating.

Graphical abstract: Block liposome and nanotube formation is a general phenomenon of two-component membranes containing multivalent lipids

Supplementary files

Article information

Article type
Paper
Submitted
20 Mar 2011
Accepted
12 May 2011
First published
20 Jun 2011

Soft Matter, 2011,7, 8363-8369

Block liposome and nanotube formation is a general phenomenon of two-component membranes containing multivalent lipids

A. Zidovska, K. K. Ewert, J. Quispe, B. Carragher, C. S. Potter and C. R. Safinya, Soft Matter, 2011, 7, 8363 DOI: 10.1039/C1SM05481C

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