Issue 22, 2011
From the journal:

Soft Matter

The in vitro characterization of dextran-based nanobubbles as possible DNA transfection agents

Agnese Bisazza,a   Andrea Civra,b   Manuela Donalisio,b   David Lembob  and  Roberta Cavalli*a  

* Corresponding authors

a Department of Science and Pharmaceutical Technology, University of Turin, via P. Giuria 9, Torino, Italy
E-mail: roberta.cavalli@unito.it
Tel: +39 011 6707825

b Department of Clinical and Biological Sciences, University of Turin, Orbassano, Torino, Italy
E-mail: david.lembo@unito.it
Tel: +39 011 6705484

Abstract

Nanobubbles consisting of a diethylaminoethyl-dextran (DEAE) shell and a perfluoropentane core were prepared as a novel DNA transfection agent. Nanobubble diameters were less than 500 nm, they possessed positive surface charge, and the ability to complex with and transfect DNA. DEAE nanobubbles present a novel platform for DNA delivery into cells that may be combined with ultrasound for imaging and targeting purposes.

Graphical abstract: The in vitro characterization of dextran-based nanobubbles as possible DNA transfection agents

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Article information

DOI
https://doi.org/10.1039/C1SM06070H
Article type
Communication
Submitted
08 Jun 2011
Accepted
16 Sep 2011
First published
11 Oct 2011

Soft Matter, 2011,7, 10590-10593

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The in vitro characterization of dextran-based nanobubbles as possible DNA transfection agents

A. Bisazza, A. Civra, M. Donalisio, D. Lembo and R. Cavalli, Soft Matter, 2011, 7, 10590 DOI: 10.1039/C1SM06070H

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