Issue 12, 1971

The safety catch principle in solid phase peptide synthesis

Abstract

N-Protected amino-acid active esters react readily with polystyrenesulphonamide yielding, after deprotection, the poly(aminoacylsulphonamides): these polymers are suitable for solid phase peptide synthesis, the completed peptide being cleaved from the resin by methylation and hydrolysis or aminolysis.

Article information

Article type
Paper

J. Chem. Soc. D, 1971, 636-637

The safety catch principle in solid phase peptide synthesis

G. W. Kenner, J. R. McDermott and R. C. Sheppard, J. Chem. Soc. D, 1971, 636 DOI: 10.1039/C29710000636

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