Re2O7-catalyzed three-component synthesis of protected secondary and tertiary homoallylic amines

Abstract

Three-component synthesis of protected secondary and “for the first time” tertiary homoallylic amines is achieved from carbonyl, carbamate, and allyltrimethylsilanes using a Re₂O₇-catalyst under mild and open flask conditions. Excellent chemoselectivities and diastereoselectivities were observed.