Issue 17, 2012

Iodine-mediated regioselective C2-amination of indoles and a concise total synthesis of (±)-folicanthine

Abstract

Highly substituted 2-aminated indoles can be prepared in moderate to excellent yields by regioselective C2-amination of indoles promoted by iodine. As a key step in a concise synthesis of (±)-folicanthine, its core structure was easily obtained by one step cyclization–dimerization of substituted tryptophan in high yield on a gram scale.

Graphical abstract: Iodine-mediated regioselective C2-amination of indoles and a concise total synthesis of (±)-folicanthine

Supplementary files

Article information

Article type
Communication
Submitted
26 Oct 2011
Accepted
05 Jan 2012
First published
10 Jan 2012

Chem. Commun., 2012,48, 2343-2345

Iodine-mediated regioselective C2-amination of indoles and a concise total synthesis of (±)-folicanthine

Y. Li, H. Wang, S. Ali, X. Xia and Y. Liang, Chem. Commun., 2012, 48, 2343 DOI: 10.1039/C2CC16637B

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