Issue 12, 2012
From the journal:

Chemical Communications

Clicking 1,2,4,5-tetrazine and cyclooctynes with tunable reaction rates†

Weixuan Chen,‡a   Danzhu Wang,‡a   Chaofeng Dai,a   Donald Hamelberga  and  Binghe Wang*a  

* Corresponding authors

a Department of Chemistry, Center for Biotechnology and Drug Design, and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, USA
E-mail: wang@gsu.edu
Tel: +1 404-413-5545

Abstract

Substituted tetrazines have been found to undergo facile inverse electron demand Diels–Alder reactions with “tunable” reaction rates.

Graphical abstract: Clicking 1,2,4,5-tetrazine and cyclooctynes with tunable reaction rates

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Article information

DOI
https://doi.org/10.1039/C2CC16716F
Article type
Communication
Submitted
30 Oct 2011
Accepted
23 Nov 2011
First published
24 Nov 2011

Chem. Commun., 2012,48, 1736-1738

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Clicking 1,2,4,5-tetrazine and cyclooctynes with tunable reaction rates

W. Chen, D. Wang, C. Dai, D. Hamelberg and B. Wang, Chem. Commun., 2012, 48, 1736 DOI: 10.1039/C2CC16716F

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