Issue 29, 2012

Pd-catalyzed and CsF-promoted reaction of bromoalkynes with isocyanides: regioselective synthesis of substituted 5-iminopyrrolones

Abstract

The palladium-catalyzed and CsF-promoted annulation reaction of bromoalkynes and isocyanides regioselectively affords a diverse set of 5-iminopyrrolone derivatives. This chemistry presumably proceeds through the bromoacrylamide intermediates, which can be readily prepared from the nucleophilic addition reaction of isocyanides to bromoalkynes in the presence of CsF.

Graphical abstract: Pd-catalyzed and CsF-promoted reaction of bromoalkynes with isocyanides: regioselective synthesis of substituted 5-iminopyrrolones

Supplementary files

Article information

Article type
Communication
Submitted
09 Dec 2011
Accepted
20 Feb 2012
First published
21 Feb 2012

Chem. Commun., 2012,48, 3545-3547

Pd-catalyzed and CsF-promoted reaction of bromoalkynes with isocyanides: regioselective synthesis of substituted 5-iminopyrrolones

Y. Li, J. Zhao, H. Chen, B. Liu and H. Jiang, Chem. Commun., 2012, 48, 3545 DOI: 10.1039/C2CC17717J

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