Issue 38, 2012
From the journal:

Chemical Communications

Photosensitizer and vancomycin-conjugated novel multifunctional magnetic particles as photoinactivation agents for selective killing of pathogenic bacteria†

Kyong-Hoon Choi,‡a   Hye-Jin Lee,‡b   Bong Joo Park,‡a   Kang-Kyun Wang,a   Eon Pil Shin,a   Jong-Chul Park,c   Young Keun Kim,d   Min-Kyu Oh*b  and  Yong-Rok Kim*a  

* Corresponding authors

a Photon Applied Functional Molecule Research Laboratory, Department of Chemistry, Yonsei University, Seoul 120-749, Republic of Korea
E-mail: yrkim@yonsei.ac.kr
Fax: +82 2-2123-2646

b Systems Bioengineering Laboratory, Department of Chemical & Biological Engineering, Korea University, Seoul 136-701, Republic of Korea
E-mail: mkoh@korea.ac.kr
Fax: +82 2-926-6102

c Department of Medical Engineering, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea

d Department of Materials Science and Engineering, Korea University, Seoul 136-713, Republic of Korea

Abstract

Novel multifunctional magnetic particles (MMPs) conjugated with photosensitizer and vancomycin were fabricated by surface modification of Fe3O4 particles. The capacities to target, capture and inactivate pathogenic bacteria and good biocompatibility suggest that the MMPs have great potentials as photodynamic inactivation agents for serious bacterial contamination.

Graphical abstract: Photosensitizer and vancomycin-conjugated novel multifunctional magnetic particles as photoinactivation agents for selective killing of pathogenic bacteria

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Article information

DOI
https://doi.org/10.1039/C2CC17766H
Article type
Communication
Submitted
12 Dec 2011
Accepted
14 Mar 2012
First published
14 Mar 2012

Chem. Commun., 2012,48, 4591-4593

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Photosensitizer and vancomycin-conjugated novel multifunctional magnetic particles as photoinactivation agents for selective killing of pathogenic bacteria

K. Choi, H. Lee, B. J. Park, K. Wang, E. P. Shin, J. Park, Y. K. Kim, M. Oh and Y. Kim, Chem. Commun., 2012, 48, 4591 DOI: 10.1039/C2CC17766H

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