Issue 33, 2012

Potent divalent inhibitors with rigid glucose click spacers for Pseudomonas aeruginosa lectin LecA

Abstract

The synthesis of a new rigid spacer based on carbohydrate-triazole repeating units and their incorporation into divalent systems is described. Inhibition studies showed that a well-matched system with a rigid spacer with flexible ends leads to the most potent inhibition of Pseudomonas aeruginosa lectin LecA.

Graphical abstract: Potent divalent inhibitors with rigid glucose click spacers for Pseudomonas aeruginosa lectin LecA

Supplementary files

Article information

Article type
Communication
Submitted
11 Jan 2012
Accepted
01 Mar 2012
First published
01 Mar 2012

Chem. Commun., 2012,48, 4008-4010

Potent divalent inhibitors with rigid glucose click spacers for Pseudomonas aeruginosa lectin LecA

F. Pertici and R. J. Pieters, Chem. Commun., 2012, 48, 4008 DOI: 10.1039/C2CC30234A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements