Issue 37, 2012
From the journal:

Chemical Communications

A dual pH and temperature responsive polymeric fluorescent sensor and its imaging application in living cells†

Liyan Yin,a   Chunsheng He,a   Chusen Huang,a   Weiping Zhu,*a   Xin Wang,a   Yufang Xu*a  and  Xuhong Qian*a  

* Corresponding authors

a State key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai, PR China
E-mail: wpzhu@ecust.edu.cn, yfxu@ecust.edu.cn, xhqian@ecsut.edu.cn
Fax: +86 21-64252603

Abstract

A polymeric fluorescent sensor PNME, consisting of A4 and N-isopropylacrylamide (NIPAM) units, was synthesized. PNME exhibited dual responses to pH and temperature, and could be used as an intracellular pH sensor for lysosomes imaging. Moreover, it also could sense different temperature change in living cells at 25 and 37 °C, respectively.

Graphical abstract: A dual pH and temperature responsive polymeric fluorescent sensor and its imaging application in living cells

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Article information

DOI
https://doi.org/10.1039/C2CC30404J
Article type
Communication
Submitted
18 Jan 2012
Accepted
19 Mar 2012
First published
19 Mar 2012

Chem. Commun., 2012,48, 4486-4488

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A dual pH and temperature responsive polymeric fluorescent sensor and its imaging application in living cells

L. Yin, C. He, C. Huang, W. Zhu, X. Wang, Y. Xu and X. Qian, Chem. Commun., 2012, 48, 4486 DOI: 10.1039/C2CC30404J

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