Issue 43, 2012

Synthesis of phenothiazinesvialigand-free CuI-catalyzed cascade C–S and C–N coupling of aryl ortho-dihalides and ortho-aminobenzenethiols

Abstract

A ligand-free CuI-catalyzed cascade C–S and C–N cross coupling of (hetero)aryl ortho-dihalides and ortho-aminobenzenethiols has been developed, and various phenothiazines were synthesized with excellent regioselectivity. A possible mechanism is proposed for the cascade coupling.

Graphical abstract: Synthesis of phenothiazines via ligand-free CuI-catalyzed cascade C–S and C–N coupling of aryl ortho-dihalides and ortho-aminobenzenethiols

Supplementary files

Article information

Article type
Communication
Submitted
04 Feb 2012
Accepted
28 Mar 2012
First published
28 Mar 2012

Chem. Commun., 2012,48, 5367-5369

Synthesis of phenothiazines via ligand-free CuI-catalyzed cascade C–S and C–N coupling of aryl ortho-dihalides and ortho-aminobenzenethiols

C. Dai, X. Sun, X. Tu, L. Wu, D. Zhan and Q. Zeng, Chem. Commun., 2012, 48, 5367 DOI: 10.1039/C2CC30814B

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