Issue 48, 2012
From the journal:

Chemical Communications

Synthesis of core–shell coordination polymernanoparticles (CPNs) for pH-responsive controlled drug release†

Lei Xing,a   Yuanyuan Caoa  and  Shunai Che*a  

* Corresponding authors

a School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Key Laboratory for Thin Film and Microfabrication Technology of the Ministry of Education, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, P. R. China
E-mail: chesa@sjtu.edu.cn

Abstract

Four types of physiologically unstable anticancer “drug-metal” CPNs were “shelled” with pH-responsive “ligand-metal” CPs, which gives rise to a significant release of drug molecules under designated pH conditions and exhibited a higher cytotoxicity against HeLa cells than core CPNs and free drug.

Graphical abstract: Synthesis of core–shell coordination polymer nanoparticles (CPNs) for pH-responsive controlled drug release

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Article information

DOI
https://doi.org/10.1039/C2CC30877K
Article type
Communication
Submitted
08 Feb 2012
Accepted
23 Apr 2012
First published
24 Apr 2012

Chem. Commun., 2012,48, 5995-5997

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Synthesis of core–shell coordination polymer nanoparticles (CPNs) for pH-responsive controlled drug release

L. Xing, Y. Cao and S. Che, Chem. Commun., 2012, 48, 5995 DOI: 10.1039/C2CC30877K

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