Issue 33, 2012

Nickel-catalysed aromatic Finkelstein reaction of aryl and heteroaryl bromides

Abstract

A fast and efficient nickel-catalysed iodination reaction of aryl and heteroaryl bromides has been developed. The transformation was found to be general for a wide range of substrates and was used for the synthesis of iodo-PK11195, an imaging agent of Alzheimer's disease and iniparib, a compound used in the treatment of breast cancer.

Graphical abstract: Nickel-catalysed aromatic Finkelstein reaction of aryl and heteroaryl bromides

Supplementary files

Article information

Article type
Communication
Submitted
09 Feb 2012
Accepted
21 Feb 2012
First published
22 Feb 2012

Chem. Commun., 2012,48, 3993-3995

Nickel-catalysed aromatic Finkelstein reaction of aryl and heteroaryl bromides

A. A. Cant, R. Bhalla, S. L. Pimlott and A. Sutherland, Chem. Commun., 2012, 48, 3993 DOI: 10.1039/C2CC30956D

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