Issue 40, 2012

Targeting the DNA-topoisomerase complex in a double-strike approach with a topoisomerase inhibiting moiety and covalent DNA binder

Abstract

RuII(arene)–flavonoids with high in vitro antitumour activity were synthesised. These compounds are capable of inhibiting human topoisomerase IIα and binding covalently to DNA.

Graphical abstract: Targeting the DNA-topoisomerase complex in a double-strike approach with a topoisomerase inhibiting moiety and covalent DNA binder

Supplementary files

Article information

Article type
Communication
Submitted
13 Feb 2012
Accepted
20 Mar 2012
First published
21 Mar 2012

Chem. Commun., 2012,48, 4839-4841

Targeting the DNA-topoisomerase complex in a double-strike approach with a topoisomerase inhibiting moiety and covalent DNA binder

A. Kurzwernhart, W. Kandioller, C. Bartel, S. Bächler, R. Trondl, G. Mühlgassner, M. A. Jakupec, V. B. Arion, D. Marko, B. K. Keppler and C. G. Hartinger, Chem. Commun., 2012, 48, 4839 DOI: 10.1039/C2CC31040F

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