Issue 43, 2012
From the journal:

Chemical Communications

Distinguishing between polymorphic forms of linezolid by solid-phase electronic and vibrational circular dichroism†

Jadwiga Frelek,a   Marcin Górecki,a   Marta Łaszcz,b   Agata Suszczyńska,a   Elemér Vassc  and  Wojciech J. Szczepek*b  

* Corresponding authors

a Institute of Organic Chemistry of the Polish Academy of Sciences, ul. Kasprzaka 44/52, 01-224 Warsaw, Poland
E-mail: jadwiga.frelek@icho.edu.pl
Fax: +48 22 632 66 81
Tel: +48 22 343 22 15

b Pharmaceutical Research Institute, ul. Rydygiera 8, 01-793 Warsaw, Poland
E-mail: w.szczepek@ifarm.eu
Fax: +48 22 456 38 38
Tel: +48 22 456 39 29

c Laboratory for Chiroptical Structure Analysis, Institute of Chemistry, Eötvös Loránd University, H-1518 Budapest, Hungary
E-mail: evass@chem.elte.hu
Fax: +36 1 372 26 20
Tel: +36 1 372 25 00 1654

Abstract

For the first time two crystalline forms of the same compound (linezolid polymorphs) were investigated by means of the solid-phase ECD and VCD spectra. The ECD spectra show distinct differences and the band at 221 nm serves as a diagnostic one because it is present in form II but absent in form III. The VCD spectra strongly differ in the diagnostic carbonyl absorption range exhibiting two relatively strong bands of opposite signs.

Graphical abstract: Distinguishing between polymorphic forms of linezolid by solid-phase electronic and vibrational circular dichroism

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Article information

DOI
https://doi.org/10.1039/C2CC31207G
Article type
Communication
Submitted
17 Feb 2012
Accepted
28 Feb 2012
First published
29 Feb 2012

Chem. Commun., 2012,48, 5295-5297

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Distinguishing between polymorphic forms of linezolid by solid-phase electronic and vibrational circular dichroism

J. Frelek, M. Górecki, M. Łaszcz, A. Suszczyńska, E. Vass and W. J. Szczepek, Chem. Commun., 2012, 48, 5295 DOI: 10.1039/C2CC31207G

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