Issue 52, 2012
From the journal:

Chemical Communications

Synthesis of isochromenones and oxepines via Pd-catalyzed cascade cyclization of alkynes and benzynes involving C–H activation†

Kanniyappan Parthasarathy,a   Han Han,a   Chandran Prakasha  and  Chien-Hong Cheng*a  

* Corresponding authors

a Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan
E-mail: chcheng@mx.nthu.edu.tw
Fax: +886-3-5724698
Tel: +886-3-5721454

Abstract

A new method for the synthesis of various isochromen-6-ones and phenanthro[1,10-bc]oxepines via a palladium-catalyzed cascade carbocyclization of 2-iodobenzyl-3-phenylpropiolates and 1-iodo-2-(2-(phenylethynyl)benzyloxy)benzenes with arynes is described. The reactions involve interesting biscarbocyclization of alkynes and benzynes and C–H bond activation.

Graphical abstract: Synthesis of isochromenones and oxepines via Pd-catalyzed cascade cyclization of alkynes and benzynes involving C–H activation

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Article information

DOI
https://doi.org/10.1039/C2CC31807E
Article type
Communication
Submitted
12 Mar 2012
Accepted
04 May 2012
First published
04 May 2012

Chem. Commun., 2012,48, 6580-6582

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Synthesis of isochromenones and oxepines via Pd-catalyzed cascade cyclization of alkynes and benzynes involving C–H activation

K. Parthasarathy, H. Han, C. Prakash and C. Cheng, Chem. Commun., 2012, 48, 6580 DOI: 10.1039/C2CC31807E

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