Issue 53, 2012

A biocatalytic redox isomerisation

Abstract

A bi-enzymatic cascade for the redox-isomerisation of allylic alcohol is presented. Coupling of an alcohol dehydrogenase to an enoate reductase has been successfully applied in one pot for the isomerisation of an allylic alcohol to the corresponding ketone. Critical parameters for yield and selectivity have been investigated.

Graphical abstract: A biocatalytic redox isomerisation

Supplementary files

Article information

Article type
Communication
Submitted
16 Mar 2012
Accepted
18 Apr 2012
First published
18 Apr 2012

Chem. Commun., 2012,48, 6630-6632

A biocatalytic redox isomerisation

S. Gargiulo, D. J. Opperman, U. Hanefeld, I. W. C. E. Arends and F. Hollmann, Chem. Commun., 2012, 48, 6630 DOI: 10.1039/C2CC31947K

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